Aqueous Synthesis of the Tiopronin-Capped Gold Nanoclusters/Nanoparticles with Precise Size Control via Deprotonation of the Ligand

Gold nanoparticles have led to numerous advances in nanomaterial-based sensors and biomedical technologies owing their chemical inertness outstanding physiochemical optical properties. are still considered one of the most promising types nanomaterials various fields, including drug delivery, cancer therapy, biomolecule detection, high-accuracy diagnosis. Surface functionalization gold with ligands modifies physicochemical properties surface, thereby improving biocompatibility uptake efficiency a living system. Tiopronin, commonly used for nanoparticles, has both thiol carboxyl functional groups that can be easily attached biomolecules. However, conventional method synthesizing tiopronin-capped nanoclusters using methanol acetic acid as solvent requires laborious time-consuming dialysis process remove acid. In this study, we demonstrate novel simple aqueous synthesis obtain nanoclusters/nanoparticles precise size control sub-nanometer nanometer range. The main advantage our is it does not require because uses water solvent. boron byproduct produced during removed volatilization process. Moreover, characterized physical morphologies, photoelectronic properties, hydrodynamic size, crystal structure transmission electron microscopy, spectrophotometry, fluorescence spectrometry, dynamic light scattering, zeta potential, X-ray diffraction.